Two people have died in the Cyclospora outbreak in Michigan, state health officials announced Monday.

Both people — whose identities were not provided — had “significant underlying health conditions that may have been impacted by cyclosporiasis and dehydration,” according to a news release.

“Cyclosporiasis is generally not a life-threatening illness,” the state health department added. “Death resulting from cyclosporiasis is uncommon in the United States.”

The deaths are the first in the U.S. related to the microscopic parasite.

The deaths come amid an unusually severe cyclosporiasis season with cases reported in 45 states, according to the Centers for Disease Control and Prevention.

Cyclospora is a microscopic, spherical parasite that commonly causes watery diarrhea “with frequent and sometimes explosive bowel movements,” according to the CDC.

The parasite infects the bowels and spreads through the fecal-oral route when a person swallows food or water contaminated with the Cyclospora parasite.

More than 11,000 cases of cyclosporiasis have been confirmed in Michigan, and 193 people have been hospitalized since early May, according to the state health department.

The outbreaks in Michigan and nine other states have been linked to lettuce at Taco Bell that was supplied by Taylor Farms and sourced from central Mexico.